extensively drug-resistant tuberculosis treatment disappointing outcomes for global public health

نویسندگان

masoud mardani infectious diseases and tropical medicine research center, shahid beheshti university of medical sciences, tehran, ir iran; infectious diseases and tropical medicine research center, shahid beheshti university of medical sciences, tehran, ir iran. tel: +98-2122439963, fax: +98-2122439964

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Extensively drug-resistant tuberculosis: an isolation order, public health powers, and a global crisis.

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Extensively drug-resistant tuberculosis.

Extensively drug-resistant (XDR) tuberculosis is defined as disease caused by Mycobacterium tuberculosis with resistance to at least isoniazid and rifampicin, any fluoroquinolone, and at least one of three injectable second-line drugs (amikacin, capreomycin, or kanamycin). The definition has applicable clinical value and has allowed for more uniform surveillance in varied international settings...

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Treatment outcomes for HIV-uninfected patients with multidrug-resistant and extensively drug-resistant tuberculosis.

BACKGROUND Multidrug-resistant (MDR) tuberculosis (TB) is more difficult to treat than is drug-susceptible TB. To elucidate the optimal therapy for MDR TB, we assessed the treatment outcomes and prognostic factors for patients with MDR TB. METHODS This study included patients who received an individualized treatment regimen for MDR TB at Samsung Medical Center, a tertiary referral hospital in...

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Extensively Drug-Resistant Tuberculosis, Pakistan

Frequency of extensively drug-resistant tuberculosis in Pakistan increased from 1.5% in 2006 to 4.5% in 2009 (p<0.01). To understand the epidemiology, we genotyped selected strains by using spoligotyping, mycobacterial interspersed repetitive units-variable number of tandem repeats, and IS6110 restriction fragment length polymorphism analysis.

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Because of these high incidences and the increasing effects of multidrug-resistant TB (MDR TB), i.e., resistant to at least both isoniazid (INH) and rifampin (RIF), the laboratory-based Taiwan Surveillance of Drug Resistance in TB (TSDRTB) program was established in 2003 (2). Surveillance demonstrated that combined drug resistance rates were 11.3% for any fi rst-line drug; and 5.3% (2004) and 4...

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Extensively Drug-Resistant Tuberculosis, Lesotho

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عنوان ژورنال:
archives of clinical infectious diseases

جلد ۸، شماره ۴، صفحات ۰-۰

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